3,4-二羟基苄胺·氢溴酸

　　中文同义词:3,4-二羟基苯甲胺氢溴酸盐,98%;3,4-二羟基苯甲胺氢溴酸盐;3,4-二羟基苄胺;3,4-二羟基苄胺氢溴酸盐;4-(氨甲基)儿茶酚氢溴酸盐;DHBA氢溴酸盐;3,4-二羟基苄胺氢溴酸盐(DHBA氢溴酸盐、4-(氨甲基)儿茶酚氢溴酸盐、3,4-二羟基苄胺.氢溴酸、3,4-二羟基苯甲胺氢溴酸盐);3,4-二羟基苄胺·氢溴酸

　　英文名称:3,4-DIHYDROXYBENZYLAMINEHYDROBROMIDE

　　英文同义词:

　　4-(AMINOMETHYL)CATECHOLHYDROBROMIDE;3,4-DIHYDROXYBENZYLAMINEHYDROBROMIDE;DHBA;DHBAHYDROBROMIDE;4-(aminomethyl)pyrocatecholhydrobromide;3,4-DIHYDROXYBENZYLAMINEHYDROBROMIDE,98%;4-(Aminomethyl)catecholhydrobromide,DHBAhydrobromide;3,4-Dihydroxybenzylamine·hydrogenbromide

　　CAS号:16290-26-9

　　分子式:C7H10BrNO2

　　分子量:220.06

　　EINECS号:240-382-8

　　相关类别:中药对照品;Anilines,AromaticAminesandNitroCompounds

　　Mol文件:16290-26-9.mol

　　结构：

　　3,4-二羟基苄胺·氢溴酸性质

　　熔点：184-186°C(lit.)

　　储存条件：Inertatmosphere,RoomTemperature

　　形态：CrystallinePowder

　　颜色：Lightbeige

　　敏感性：Hygroscopic

　　BRN：4002646

　　CAS数据库：16290-26-9(CASDatabaseReference)

　　3,4-二羟基苄胺·氢溴酸用途与合成方法

　　生物活性：3,4-Dihydroxybenzylaminehydrobromide(NSC263475hydrobromide)是一种结构改良的多巴胺类似物细胞毒物，抑制黑色素瘤细胞中DNA聚合酶(DNApolymerase)活性。3,4-Dihydroxybenzylaminehydrobromide在不同程度的酪氨酸酶活性的黑色素瘤细胞系中显示不同的生长抑制活性。

　　体外研究：

　　3,4-Dihydroxybenzylaminehydrobromide(1μM-10mM;48hours)inhibitsthegrowthofallmelanomacelllineswithanIC50of100μM,whiletheSK-MELBcelllineexhibitsanIC50of122μM.TheIC50valuesare30,84,90,and68μMforHumanSK-MEL-30,SK-MEL-2,SK-MEL-3,RPMI-7951cells,respectivelyChemicalbook.ItexhibitsIC50valuesof10,25,67,and184μMforS91A,S91B,L1210,andSCC-25cells,respectively.3,4-Dihydroxybenzylaminehydrobromide(1μM-10mM;48hours)cytotoxicityinSK-MEL-2andSK-MEL-28celllinescanbeenhancedbyapplicationofbuthioninesulfoximine(BSO).BSOtreatmentsensitizesmarginallypigmentedcellstotheeffectsof3,4-DHBA,andthepresenceofdecresesIC50valuesof3,4-DHBAby127%intheSK-MEL-28celllineandby148%intheSK-MEL-2cellline.CellViabilityAssayCellLine:HumanandMurineMelanomaCellLines;Non-MelanomaCellLinesConcentration:1μM-10mMIncubationTime:48hoursResult:InhibitedmelanomacellLinesgrowth.

　　体内研究：

　　3,4-Dihydroxybenzylaminehydrobromide(intraperitonealinjection;1000mg/kg;7days)hastheleasttoxiceffectinnon-tumor-bearingB6D2F1mice,andmiceistoleratedatthisdose.3,4-Dihydroxybenzylaminehydrobromide(intraperitonealinjection;200-800mg/kg;21days)hasdifferenteffectsatdifferentdoses,themedianlife-spanare17,24.5,26,29and25daysfor0mg/kg,200mg/kg,400mg/kg,600mg/kg,and800mg/kg,respectively.AnimalModel:C57BL/6micewithB6D2F1cellsDosage:200mg/kg,400mg/kg,600mg/kg,and800mg/kgAdministration:IntraperitonealinjectionResult:Exhibitedincreasedlife-spanof44%,46%,70%and50%for200mg/kg,400mg/kg,600mg/kg,and800mg/kg,respectively.

　　安全信息

　　危险品标志：Xi

　　危险类别码：36/37/38

　　安全说明：26-36

　　WGKGermany：3

　　F：10

　　海关编码：29222900